BackgroundAntipsychotic-induced weight gain is a contributing factor in the reduced life expectancy reported amongst people with psychotic disorders. CYP2D6 is a liver enzyme involved in the metabolism of many commonly used antipsychotic medications. We investigated if CYP2D6 genetic variation influenced weight or BMI among people taking antipsychotic treatment.MethodsWe conducted a systematic review and a random effects meta-analysis of publications in Pubmed, Embase, PsychInfo, and CENTRAAL that had BMI and/or weight measurements of patients on long-term antipsychotics by their CYP2D6-defined metabolic groups.ResultsTwelve (...) studies were included in the systematic review. All cohort studies suggested that the presence of reduced-function or non-functional alleles for CYP2D6 was associated with greater antipsychotic-induced weight gain, whereas most cross-sectional studies did not find any significant associations. Seventeen studies were included in the meta-analysis with clinical data of 2,041 patients, including 93 poor metabolizers, 633 intermediate metabolizers, 1,272 normal metabolizers, and 30 UMs. Overall, we did not find associations in any of the comparisons made. The estimated pooled standardized differences for the following comparisons were PM versus NM; weight = –0.07, BMI = 0.40. IM versus NM; weight = 0.09 and BMI = 0.09. UM versus EM; weight = 0.01 and BMI = –0.08.ConclusionOur systematic review of cohort studies suggested that CYP2D6 poor metabolizers have higher BMI than normal metabolizers, but the data of cross-sectional studies and the meta-analysis did not show this association. Although our review and meta-analysis constitutes one of the largest studies with comprehensively genotyped samples, the literature is still limited by small numbers of participants with genetic variants resulting in poor or UMs status. We need further studies with larger numbers of extreme metabolizers to establish its clinical utility in antipsychotic treatment. CYP2D6 is a key gene for personalized prescribing in mental health. (shrink)

In the work of both Ludwik Fleck and Thomas Kuhn the scientific literature plays important roles for stability and change of scientific phenomenal worlds. In this article we shall introduce the analyses of scientific literature provided by Fleck and Kuhn, respectively. From this background we shall discuss the problem of how divergent thinking can emerge in a dogmatic atmosphere. We shall argue that in their accounts of the factors inducing changes of scientific phenomenal worlds Fleck and Kuhn offer substantially different (...) approaches, and we shall discuss in which respects their approaches may be compatible. (shrink)

This Festschrift bears impressive testimony to the fascination which Icelandic and Norwegian sagas and Faroese ballads still exercise on researchers. Fifteen original papers examine central literary and historical aspects of Nordic sagas and ballads. The papers are published in German, English or Danish.

BackgroundDecision-making in out-of-hospital cardiac arrest should ideally include clinical and ethical factors. Little is known about the extent of ethical considerations and their influence on prehospital resuscitation. We aimed to determine the transparency in medical records regarding decision-making in prehospital resuscitation with a specific focus on ethically relevant information and consideration in resuscitation providers’ documentation.MethodsThis was a Danish nationwide retrospective observational study of out-of-hospital cardiac arrests from 2016 through 2018. After an initial screening using broadly defined inclusion criteria, two experienced (...) philosophers performed a qualitative content analysis of the included medical records according to a preliminary codebook. We identified ethically relevant content in free-text fields and categorised the information according to Beauchamp and Childress’ four basic bioethical principles: autonomy, non-maleficence, beneficence, and justice. ResultsOf 16,495 medical records, we identified 759 (4.6%) with potentially relevant information; 710 records (4.3%) contained ethically relevant information, whereas 49 did not. In general, the documentation was vague and unclear. We identified four kinds of ethically relevant information: patients’ wishes and perspectives on life; relatives’ wishes and perspectives on patients’ life; healthcare professionals’ opinions and perspectives on resuscitation; and do-not-resuscitate orders. We identified some “best practice” examples that included all perspectives of decision-making. ConclusionsThere is sparse and unclear evidence on ethically relevant information in the medical records documenting resuscitation after out-of-hospital cardiac arrests. However, the “best practice” examples show that providing sufficient documentation of decision-making is, in fact, feasible. To ensure transparency surrounding prehospital decisions in cardiac arrests, we believe that it is necessary to ensure more systematic documentation of decision-making in prehospital resuscitation. (shrink)

This collection of essays in honor of Prof. Stig Andur Pedersen's 60th Birthday spans over a broad scope of topics, ranging from mathematical modelling over realism in philosophy of science to an analysis of apology after medical mistakes. The unusually broad range is a fair but still inadequate reflection of the work of Stig Andur Pedersen, a philosopher and scientist whose range of interests, abilities and production is itself unusually broad.

One important problem concerning incommensurability is how to explain that two theories which are incommensurable and therefore mutually untranslatable and incomparable in a strictly logical, point-by-point way are still competing. The two standard approaches have been to argue either that the terms of incommensurable theories may share reference, or that incommensurable theories target roughly the same object domain as far as the world-in-itself is concerned. However, neither of these approaches to the problem pay due respect to the incommensurability thesis' insights. (...) In this paper I shall first show the inconsistency between the basic premises underlying Kuhn’s incommensurability thesis and the two standard responses to the thesis. I shall then argue that if one adopts Kuhn’s position, the response must build on a notion of overlap between phenomenal worlds. Finally, I shall argue that overlap between complex structures of features can provide the basis for such a notion, and that this makes it possible to explain how incommensurable theories may compete. (shrink)

It is a commonly raised argument against thefamily resemblance account of concepts that, on thisaccount, there is no limit to a concept's extension.An account of family resemblance which attempts toprovide a solution to this problem by including bothsimilarity among instances and dissimilarity tonon-instances has been developed by the philosopher ofscience Thomas Kuhn. Similar solutions have beenhinted at in the literature on family resemblanceconcepts, but the solution has never received adetailed investigation. I shall provide areconstruction of Kuhn's theory and argue that (...) hissolution necessitates a developmental perspective withbuilds on both the transmission of taxonomies betweengenerations and a progressive development throughhistory. (shrink)

The Golden Age of postwar capitalism has been eclipsed, and with it seemingly also the possibility of harmonizing equality and welfare with efficiency and jobs. Most analyses believe that the emerging postindustrial society is overdetermined by massive, convergent forces, such as tertiarization, new technologies, or globalization, all conspiring to make welfare states unsustainable in the future. Social Foundations of Postindustrial Economies takes a second, more sociological and more institutional, look at the driving forces of economic transformation. What, as a result, (...) stands out is postindustrial diversity, not convergence. Macroscopic, global trends are undoubtedly powerful, yet their influence is easily rivalled by domestic institutional traditions, by the kind of welfare regime that, some generations ago, was put in place. It is, however, especially the family economy that hold the key as to what kind of postindustrial model will emerge, and to how evolving tradeoffs will be managed. Twentieth-century economic analysis depended on a set of sociological assumptions that, now, are invalid. Hence, to better grasp what drives today's economy, we must begin with its social foundations. (shrink)

This paper discusses the Uniqueness Thesis, a core thesis in the epistemology of disagreement. After presenting uniqueness and clarifying relevant terms, a novel counterexample to the thesis will be introduced. This counterexample involves logical disagreement. Several objections to the counterexample are then considered, and it is argued that the best responses to the counterexample all undermine the initial motivation for uniqueness.

This chapter uncovers a less investigated aspect of the relationship between the two most important scholastic schools of the Renaissance, Thomism and Scotism: the influence of Scotist literature on distinctions as seen in some sixteenth-century Thomists. The chapter has a primary focus on Chrysostomus Javelli’s engagement in his discussion of divine attributes with the Scotist doctrine of distinctions, but also considers other Thomist sources. First, the beginnings of the highly specialised Scotist literature on distinctions are traced back to the start (...) of the fourteenth century; I show how some early followers of Duns Scotus, in particular Francis of Meyronnes and Petrus Thomae, systematised Scotus’ ontology of the various grades of being by compiling lists of subtle distinctions to be applied to various levels of reality. I give some indications as to the later reception of these models of distinctions in the Scotist school. Special attention is paid to Étienne Brulefer, since his summary of Petrus Thomae’s model of seven distinctions was Javelli’s source for the Scotist doctrine. I then investigate how Javelli worked with Brulefer’s summary, and how he sought to integrate the Scotist doctrine into his own discussion of divine attributes. Thomists traditionally allowed only a rational or mental kind of distinction among divine attributes, and between them and the divine essence. Javelli, however, endeavours to show how the Thomist position may be reconciled with the Scotist doctrine of a formal or ex natura rei distinction. He did not always endorse this conciliatory approach; I hypothesise that he changed his mind on the subject over time. Finally, I show how other Renaissance Thomists reacted to the Scotist system of distinctions; in particular, I draw attention to the Thomists Andreas Bodenstein von Karlstadt, Bartolomeo Manzoli, and Mattia Gibboni da Aquario, who all wrote treatises on Thomist distinction theory modelled on the Scotist system of distinctions. In some of this literature, lists of distinctions based on Thomist metaphysics were compiled in order to replace the Scotist system. I argue that Javelli’s approach is more conciliatory and, in fact, has some overlap with the concordist thought of Giovanni Pico della Mirandola, who himself considered Scotus and Aquinas to be in fundamental agreement as regards the distinction between divine attributes. (shrink)

Scientific Change How do scientific theories, concepts and methods change over time? Answers to this question have historical parts and philosophical parts. There can be descriptive accounts of the recorded differences over time of particular theories, concepts, and methods—what might be called the shape of scientific change. Many stories of scientific change attempt to give […].

This paper extends Mori’s (IEEE Robot Autom Mag 19:98–100, 2012) uncanny valley-hypothesis to include technologies that fail its basic criterion that uncanniness arises when the subject experiences a discrepancy in a machine’s human likeness. In so doing, the paper considers Mori’s hypothesis about the uncanny valley as an instance of what Heidegger calls the ‘challenging revealing’ nature of modern technology. It introduces seeming autonomy and heteronomy as phenomenological categories that ground human being-in-the-world including our experience of things and people. It (...) is suggested that this categorical distinction is more foundational than Heidegger’s existential structures and phenomenological categories. Having introduced this novel phenomenological distinction, the paper considers the limits of Mori’s hypothesis by drawing on an example from science fiction that showcases that uncanniness need not only be caused by machines that resemble human beings. In so doing, it explores how the seeming autonomy-heteronomy distinction clarifies (at least some of) the uncanniness that can arise when humans encounter advanced technology which is irreducible to the anthropocentrism that shapes Mori’s original hypothesis. (shrink)

If we want to understand why mathematical knowledge is extraordinarily reliable, we need to consider both the nature of mathematical arguments and mathematical practice as a social practice. Mathematical knowledge is extraordinarily reliable because arguments in mathematics take the form of deductive mathematical proofs. Deductive mathematical proofs are surveyable in the sense that they can be checked step by step by different experts, and a purported proof is only accepted as a proof by the mathematical community once a number of (...) experts have checked the proof. Hence, the reliability of the body of mathematical knowledge is in part obtained through the surveyability of proofs and the social process of proof validation. This chapter reviews work relating to (1) the norm in the mathematical community of only counting as argument deductive mathematical proof, and (2) the norm of only counting as deductive mathematical proof an argument that has been confirmed to be a deductive mathematical proof by a number of experts. The chapter also presents cases of unusual mathematical proofs or arguments that challenge these norms. (shrink)

Language is infused with materiality and should therefore not be considered as an abstract system that is isolated from socio-material reality. Expressions materialise language in social practices, thus providing the necessary basis for languaging activities. For this reason, it makes sense to challenge proponents of orthodox linguistics and others who hold that language can be studied in isolation from its concrete manifestations. By exploring the relation between materiality and linguistic activity, the article extends Malafouris’ Material Engagement Theory while clarifying the (...) phenomenon of ‘linguistic denotation’. In so doing, it critiques orthodox approaches to language which trace denotation to abstract meanings and/or mental representations. The article shows how the denotative aspects of language can be cashed out in non-representational terms and, furthermore, that the interrelation of denotation and materiality is crucial to human material culture in that it allows for material engagements to transcend localised contexts. These engagements become global in Latour’s sense and, in so doing, denotation ceases to demand descriptions in terms of representations. (shrink)

Abstract: This paper explores the relevance of themes from Wittgenstein's Tractatus Logico-Philosophicus to the ongoing discussion of metaphysical nihilism. I set out by showing how metaphysical nihilism is of paramount importance for cosmological arguments. Metaphysical nihilism is the position that there might have been nothing. Two conflicting intuitions emerge from a survey of discussions of metaphysical nihilism: Firstly, that metaphysical nihilism is true, and secondly, that formulations of the position are somehow unclear or nonsensical. By considering formalizations of philosophical language, (...) the second intuition is sharpened, while the first intuition is given expression through the Tractarian distinction between what is said and what is shown by our symbolism. I conclude by exploring and rejecting objections to making metaphysical nihilism a scientific, rather than a philosophical question. (shrink)

The paper reviews the current state of play around anti-representationalist attempts at countering Clark and Toribio’s representation-hunger thesis. It introduces a distinction between different approaches to Chemero’s Radical embodied cognition thesis in the form of, on the one hand, those pushing a hard line and, on the other, those who are more relaxed about their anti-representationalist commitments. In terms of overcoming Clark and Toribio’s thesis, hardliners seek to avoid any mentioning of mental content in the activity they purport to explain. (...) Yet, the paper argues, adopting a hard line complicates this endeavor considerably and unnecessarily. Those promoting a relaxed REC, however, are better off in that they have no problem in recognizing that some types of cognition are hybrid. By turning to Hutto and Myin’s Radical Enactivism as a prime example of a relaxed approach to the REC thesis, the paper points towards the lack of continuity between covariant information and informational content as the gap that would necessarily have to be closed in order for RECers to, once and for all, be able to dismiss Clark and Toribio’s hypothesis that certain kinds of cognition are per definition off-limits to anti-representationalism. (shrink)

The purpose of this paper is to show that the methods of determining monetary values of biodiversity depend on one's ethical point of departure. After a short summary of the ethical principles of anthropocentrism and biocentrism, the paper discusses the problem wether we shouldextend the market system and let the price mechanism encompass biological diversity, i.e. put prices on biodiversity. Basically, the anthropocentric approach leads to an ethics of freedom, where the individual has the right to decide what is good (...) and to implement it. Then the individual's willingness to pay for biodiversity is a relevant criterion for its price. But the biocentric approach rather implies that an ethic of law is more important, valuing the real needs of Nature higher than the preferences of the individual consumers. Then the costs for protection or replacement are relevant, because they reflect what Nature needs.One further question concerns who is to decide the proces of biodiversity. If the willingness to pay is the criterion, then obviously the market should decide, using well-developed methods. If on the other hand the costs of protection or replacement are relevant, technical and economic experts have to calculat them—given the politically decided level of biodiversity to be restored.The basic question, whether the market and the price mechanism should be considered acceptable instruments to protect biodiversity, is not discussed in the paper. However, some environmentalists find the wish to maximize one's utility incompatible with environmental ethics. Also, the price mechanism may take various roles. Thus, prices may convey different information about the value of biodiversity, depending on which role we assign to them. (shrink)

This book explores two questions that are integral to the question of the existence of God. The first question concerns the meaning of "existence" and the second concerns the meaning of "God". Regarding the first question, this book motivates, presents and defends the meta-ontology found in Gottlob Frege's writings and defended by Michael Dummett, Crispin Wright and Bob Hale. Frege's approach to questions of existence has mainly found use in connection with abstract objects such as numbers. This is one of (...) the first studies to systematically present Fregean meta-ontology and apply it to theology. Frege's meta-ontology is informed by his context principle. According to this, logico-syntactic notions such as "singular term" and "predicate" are pivotal to questions of what exists. These notions serve to throw light on the second question. Through thorough engagement with Old as well and New Testament texts, the book shows how Frege's logico-syntactic notions are of crucial importance when seeking to understand the meaning and use of "God". To complete the defence of Fregean meta-ontology, the book concludes by pointing to important differences between the otherwise closely associated concepts of an object found in Wittgenstein's Tractatus Logico-Philosophicus and Frege's writings. (shrink)

It is a well-established fact in representationalist cognitive science that concrete concepts influence human perception. In radical, anti-representationalist cognitive science, however, the case is far from clear. One reason for this is that proponents of Radical Enactivism yet have to clarify whether perceptual activity involving concepts is bound to rely on mental content or if it instantiates basic, contentfree cognition. The purpose of this paper is to show that concept-involving perception instantiates REC-style basic cognition. The paper begins by considering ‘cognitive (...) projection’ as the term is introduced by Distributed Cognition research. Although being introduced as a means for exploring concept-based perception in non-representationalist terms, I argue that ‘cognitive projection’ comes with mentalist overtones and unclarities concerning its linguistic basis. With the purpose of overcoming these shortcomings, I unfold a REC-friendly reading of Wittgenstein’s writings on aspect perception, arguing that basic concept-involving perception is an instantiation of basic cognition. Concludingly, with the aim of ensuring compatibility, I make a connection between conceptual aspect perception and the REC notion of attentional anchors. The latter has been introduced to explore the role of material artefacts in the context of science, technology, engineering, and mathematics educational design but has, I submit, the potential for being extended to other practical contexts. (shrink)

Postphenomenologists and performativists criticize classical approaches to phenomenology for isolating human subjects from their socio-material relations. The purpose of this essay is to repudiate their criticism by presenting a nuanced account of phenomenology thus making it evident that phenomenological theories have the potential for meshing with the performative idiom of contemporary science and technology studies. However, phenomenology retains an apparent shortcoming in that its proponents typically focus on human–nonhuman relations that arise in localized contexts. For this reason, it seems to (...) contrast with one of the core assumptions behind practical ontologies: that socio-practical significance extends beyond an agent’s immediate situatedness in a localized context. Turning to Heidegger’s phenomenology and his notion of ‘de-distancing’, the essay explores how localized phenomena that pertain to human experience connect with global practices and, thus, the possibility of consilience between phenomenological research and present-day STS. (shrink)

Lewis, D. Semantic analyses for dyadic deontic logic.--Salomaa, A. Some remarks concerning many-valued propositional logics.--Chellas, B. F. Conditional obligation.--Jeffrey, R.C. Remarks on interpersonal utility theory.--Hintikka, J. On the proper treatment of quantifiers in Montague semantics.--Mayoh, B.H. Extracting information from logical proofs.--Åqvist, L. A new approach to the logical theory of actions and causality.--Pörn, I. Some basic concepts of action.--Bouvère, K. de. Some remarks concerning logical and ontological theories.--Hacking, I. Combined evidence.--Äberg, C. Solution to a problem raised by Stig Kanger (...) and a set theoretical statement equivalent to the axiom of choice.--Lindström, P. On characterizing elementary logic.-- Scott, D. Rules and derived rules.--Hansson, B. A program for pragmatics.--Hermerén, G. Models.--Fenstad, J.E. Remarks on logic and probability.--Stenlund, S. Analytic and synthetic arithmetical statements. (shrink)

`Proto-idea' was a central concept in the thinking of the Polish microbiologist and philosopher of science Ludwik Fleck (1896–1961). Based on studies of the origin of the modern concept of syphilis, Fleck claimed that many established scientific facts are best understood as interpretations of pre scientific, somewhat hazy `proto-ideas' in the framework of a certain `thought-style'. As an example,Fleck saw the modern knowledge of infection as an interpretation of the ancient proto-idea of diseases as caused by minute `animalcules'. However, the (...) epistemological aspects of the concept of proto-ideas have only been sparsely developed and discussed by Fleck and his critics. This paper attempts to bridge the gap. Firstly, I reconstruct the concept of proto-ideasin the context of Fleck's constructivist theory of knowledge. Secondly, I illustrate the relation between Fleck's concept of proto-ideas and his nominalist view on medical taxonomy. Finally, I discuss four philosophical problems implied by Fleck's concept of proto-ideas: (a) the problem of combining two conflicting perspectives on the history of science (b) the problem of accounting for the notion of` continuity' within a non realist theory of knowledge (c) the problem of ascribing no truth-content to proto-ideas, and (d) the problem concerning the non-neutrality of the analyst's viewpoint. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2018 Heft: 225 Seiten: 77-102.

The first section of this paper introduces talk about absolutely everything -- the world as a totality -- as an integral element in the project of natural theology, as it has been presented by Fergus Kerr and Denys Turner respectively. The following section presents talk about the world as a totality of facts as a theme in philosophical logic and outlines a problem it has given rise to there. After confronting the solution originally suggested by Bertrand Russell and defended by (...) David Armstrong, the paper points to key elements of the solution presented by Wittgenstein in Tractatus Logico-Philosophicus. I show how Wittgenstein’s answer to the question of unrestricted quantification draws on his notion of showing and the inexpressible. Against this background, the concluding section draws attention to an important difference in ambition between Kerr’s and Turner’s description of the prospects for natural theology. (shrink)

In a previous article we have shown that Kuhn's theory of concepts is independently supported by recent research in cognitive psychology. In this paper we propose a cognitive re-reading of Kuhn's cyclical model of scientific revolutions: all of the important features of the model may now be seen as consequences of a more fundamental account of the nature of concepts and their dynamics. We begin by examining incommensurability, the central theme of Kuhn's theory of scientific revolutions, according to two different (...) cognitive models of concept representation. We provide new support for Kuhn 's mature views that incommensurability can be caused by changes in only a few concepts, that even incommensurable conceptual systems can be rationally compared, and that scientific change of the most radical sort—the type labeled revolutionary in earlier studies—does not have to occur holistically and abruptly, but can be achieved by a historically more plausible accumulation of smaller changes. We go on to suggest that the parallel accounts of concepts found in Kuhn and in cognitive science lead to a new understanding of the nature of normal science, of the transition from normal science to crisis, and of scientific revolutions. The same account enables us to understand how scientific communities split to create groups supporting new paradigms, and to resolve various outstanding problems. In particular, we can identify the kind of change needed to create a revolution rather precisely. This new analysis also suggests reasons for the unidirectionality of scientific change. (shrink)